The Artacleanse® Process
The Artacleanse process is performed in Tides Medical’s AATB® Accredited Tissue Bank by expert technicians. Every Artacleanse labeled product begins with donated placental tissue from a planned C-section. From collection in the operating room to the final packaging, the tissue remains in its own sterile field, safe from contamination.
Tides Medical’s proprietary aseptic process is strong enough to provide a cleansed and decellularized dehydrated human amniotic membrane (dHAM), but gentle enough to retain essential growth factors and signaling molecules naturally bound to the extracellular matrix.
Artacleanse processed, decellularized dHAM supplies an intact basement membrane of collagens (I, III, IV, V, VI), fibronectin, laminin, nidogen, and other proteoglycans to the healing site. An intact scaffold is critical for organized tissue reconstruction, rather than scar tissue formation1,2.
Signaling Molecules Present in Artacleanse Processed dHAM3
Extracellular Matrix Components in Human Amniotic Membrane2
Functions of the Extracellular Matrix2
- Mechanical support
- Storage and presentation of regulatory molecules
- Control of cell growth
- Establishment of tissue microenvironments
- Scaffolding for renewal
- Maintenance of cell differentiation
Key Benefits of Amniotic Tissues
- Shown to stimulate healing and to reduce scar tissue and inflammation.
- Essential, native growth factors retained by minimal processing.
- Used clinically for over 100 years with more than 100 publications to date.4
Artacleanse® processed dehydrated amniotic tissue is regulated by Section 361 of the Public Health Service Act by the United States Food and Drug Administration (FDA). Artacleanse® processed dehydrated allografts are minimally manipulated and intended for homologous use.
1Kumar, V., Fausto, N., Abbas, A. and Mitchell, R. (2008). Robbins basic pathology. Philadelphia, Pa: W.B. Saunders, pp.64-79.
2Niknejad, H., Peirovi, H., Jorjani, M., Ahmadiani, A., Ghanavi, J., & Seifalian, A. (2008). Properties of the amniotic membrane for potential use in tissue engineering. European Cells and Materials, 7, 88-99.
3Data on file.
4Fairbairn et al, The clinical applications of human amnion in plastic surgery. J Plast Reconstr Aesthet Surg. 2014. Jan 31. pii:S1748-6815(14)00037-0.